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This US postal stamp helped fund key breast cancer study
05 June 2018, 07:42 | Melissa Porter
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Sparano concluded that in women with HR-positive, HER2-negative, AN-negative breast cancer who had a RS of 11 to 25, adjuvant ET was not inferior to CET in the ITT analysis.
Dr. Otis Brawley, chief medical and scientific officer for the American Cancer Society said that he was "delighted" by the study and anxious about unnecessary cancer treatment and the side effects that come from chemotherapy.
According to the American Cancer Society, one in eight women will develop breast cancer in her life. "The study showed that if you take the group as a whole, there is no difference in the risk of recurrence when you compare chemotherapy to no chemotherapy".
However, certain women 50 or younger will still benefit from having chemotherapy.
Sunday's results came from a federally sponsored trial called TailorX, which was created to help doctors more precisely tailor treatments for early-stage breast cancer.
Dr. Lisa Carey, a breast specialist at the University of North Carolina's Lineberger Comprehensive Cancer Center, said she would be very comfortable advising patients to skip chemo if they were like those in the study who did not benefit from it.
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The results show that all women over 50 with a recurrence score of 0 to 25 can be spared chemotherapy and its toxic side effects. Since 2006, the trial has enrolled more than 10,000 women in the United States and five other countries diagnosed with early breast cancer and followed their progress through post-surgery treatment.
The study is limited in some ways. A key part - the initial $4.5 million of the cancer institute's $36 million contribution - came from the stamp, said Dinah Singer, who is involved in the institute's use of stamp proceeds.
Researchers say many women with early-stage breast cancer might not need chemotherapy.
They found these women may benefit from surgery and hormone therapy and may not have to go through chemotherapy treatments.
A high recurrence score, above 25, means chemo is advised to ward off a recurrence, while a low score, below 10, means it is not. Others want chemo for even the smallest chance of benefit.
But doctors have been unsure how to treat women with scores in the intermediate range of 11 and 25.
"I don't ever think I'll ever have the feeling that I'm completely out of the woods, but this definitely is exciting and makes me feel good", Mall said.
Researchers at the National Cancer Institute have put a patient with metastatic breast cancer into complete remission by using a new approach to immunotherapy.
"A lot of work needs to be done, but the potential exists for a paradigm shift in cancer therapy - a unique drug for every cancer patient", he said.
Breast Cancer Now also called for Nice to reflect the findings in its guidance. "We want to give the right amount", he said.
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