ibusinesslines.com
ibusinesslines.com October 17, 2018


New Cure For Common Cold Targets Human Protein Instead Of Virus

15 May 2018, 03:29 | Melissa Porter

From the Inventor of Viagra New Molecule Promise of'Irresistible Cold CureCC0

Common cold

The Imperial College researchers reported that IMP-1088 blocked the common cold without affecting healthy cells. All treatments against the cold are to treat the symptoms like a runny nose, fever or a sore throat. This new drug, however, did not damage cultured human cells.

Also, because the molecule targets human cells rather than the virus, resistance would not be an issue.

The drug works by suppressing a human enzyme that cold viruses use to construct their capsids - the armoured outer shell of a virus.

We often talk about the common cold like it's one illness caused by one germ, but in reality, a cold can be triggered by nearly 200 different viruses.

Users would have to take the drug early on in a cold infection, and the researchers are working on a version which could be inhaled.

When tested on human cells in a dish, the drug was found to block several strains of cold virus from replicating, without having any effect on the cells. In fact, it should also work against the related viruses that cause foot-and-mouth disease and polio.

"The common cold is an inconvenience for most of us, but can cause serious complications in people with conditions like asthma and COPD", said lead researcher Ed Tate, a professor of chemistry at Imperial College, in the statement.


The molecule targets a human protein and not the virus itself, making emergence of resistant viruses highly unlikely.

"All strains of the virus need this same human protein to make new copies of themselves, so the molecule should work against all of them", Dr Jim Brannigan, from the University of York's Department of Chemistry, said in a statement.

However, the discovery of a new molecule, code-named IMP-1088, offers a slightly different approach to the problem by treating the human cells. Further study is needed to make sure it is not toxic in the body.

Roberto Solari, visiting Fellow at the National Heart & Lung Institute, says he's reasonably optimistic.

This article has been republished from materials provided by Imperial College London.

They screened a large volume of different compounds looking for a molecule that specifically targeted NMT. Note: material may have been edited for length and content.



Other News

Trending Now

Prosecutor says suspected abuse of children constitutes torture
She said that she was the one who called authorities about her missing 12-year-old, The Washington Post reported . Allen stated she is estranged from her son and that he has saved his household away from the youngsters.

Netflix orders anthology horror series 10 After Midnight from Guillermo del Toro
The Academy Award-winning filmmaker will also have the third season of the animated kids program Trollhunters released on May 25. If this is your brand of TV, then you're going to love what the visionary, del Toro, has in store for you.

Happy 1 month, True: Khloe Kardashian debuts her baby
She's since deleted the post, but the omission of new mom Khloe and mother of three Kourtney was really telling. Cait also said last year that Khloe hasn't talked to her "in, like, two years".

Brazil defender Alves ruled out of World Cup with knee injury
Brazil is in Group E with Switzerland, Costa Rica, and Serbia and they will take on Switzerland in their opening game on June 17. Which player will you miss at this year's World Cup? "If we win the World Cup , I will not be screaming, for once, I promise".

Poor People's Campaign launches 40 days of protesting poverty
The aim, organizers said, is to ensure lawmakers address the issues and help reclaim the nation's "deteriorating" moral narrative. Forty-nine people were cited by Raleigh police for impeding traffic by standing in the street, a misdemeanor, police Capt.

U.S. defense attache leaves Pakistan
Richard Snelsire, a spokesman for the U.S embassy in Islamabad , did not wish to comment when contacted by Anadolu Agency. The Islamabad High Court on Friday ordered the Interior Ministry to put the diplomat's name on its Exit Control List.

O'Brien leads Irish fightback with century on debut
He would bring up the first Test century for Ireland late in the day to tap a fine day of resistance with a very special moment.