In head-to-head statistics, these two sides have met on 134 occasions, with Spurs claiming 52 wins compared to City's 51, while 31 matches have ended in stalemates.
If City score a victory over Spurs, then Manchester United will have to beat Newcastle to delay the celebrations for at least another week.
Manchester City (87pts) will clinch the title with one more win from their last five games, or defeat for Manchester United (71) against West Brom or Bournemouth. Liverpool (70) and Tottenham (67) look set to finish in the top four with Chelsea seven points behind in fifth.
Harry Kane will be heading into the contest hoping to further his challenge against Mohamed Salah for the Premier League's Golden Boot, a battle that has been kept interesting after Kane was awarded Tottenham's second goal at Stoke after an appeal.
Pep Guardiola's men have lost their last three games, going out of the Champions League while also missing the chance to wrap up the Premier League title by throwing away a 2-0 lead to go down 3-2 to Manchester United.
Sergio Aguero is also a doubt following a knee complaint after the Liverpool clash this week, meaning Gabriel Jesus could, as expected start up front.
Pochettino has hinted that Toby Alderweireld will continue on the sidelines despite being fully fit so Davinson Sanchez should start alongside Vertonghen in the middle of the back four. But counter-attacking speed might be more important here.
Another target United are said to me monitoring is Tottenham'sDanny Rose, and should United sign the Englishman, this would free up space at Spurs.
Chelsea are realistically the only side who could yet catch Tottenham. Our guide reveals all you need to know to watch Tottenham vs Man City online, including full live stream details and the kick-off time.
"We need to keep pushing, winning games and this is a massive three points against Manchester City".
The Tottenham striker has won the accolade in both of the last two seasons and could be on course to make it a hat-trick if he can close the gap on the Egyptian, who now leads him by four goals on 29.
United Nations chief warns against escalation over Syria
Turkish Foreign Ministry in a statement welcomed the strikes as an appropriate response to the suspected chemical attack. United Nations Secretary-General Antonio Guterres says "the Cold War is back with a vengeance but with a difference".
Putin: attack on Syria act of aggression
President Donald Trump said he was prepared to sustain the response until Assad's government stopped its use of chemical weapons. Syria fired surface-to-air missiles in response to the attacks but Russian Federation said it did not.
Indian trailblazer Kom wins Commonwealth boxing gold at last
Australia will attempt to win its sixth consecutive gold in men's field hockey when it plays New Zealand on Saturday evening. Nigeria's Suwaibidu Galadima on Friday won gold in the men's T47 100m at the Gold Coast 2018 Commonwealth Games .