It will be their earliest meeting since the sisters' first match in the series, a straight-sets victory by Venus in the second round of the 1998 Australian Open.
The fans' reaction in California came after Venus pulled out of her semifinal with Serena just before the tussle, citing a knee injury.
That this is Indian Wells, a tournament that holds plenty of history for the Williams sisters, makes it an even more loaded contest.
Serena chose to return in 2015, whilst Venus came back to Indian Wells in 2016.
Monday's meeting will be the 29th between the pair, with Serena leading 17-11.
"I literally didn't even think about it", Serena replied, when asked whether she was happy the match would finally get to take place. There is obviously some rust for arguably the greatest to ever do it, but to win back-to-back matches without dropping a set is a fairly astounding feat for someone playing for the first time in 14 months. I have a long way to go.
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Open champion who lost to Federer in the final of this year's Australian Open, eased to a 7-5, 6-3 victory over Marton Fucsovics. So it was definitely nerve-wracking kind of, but I was enjoying it so much out there and I was playing my best.
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Those games will be Southgate's last chance to experiment before naming his 23-man squad for the World Cup in Russian Federation . Marcus Rashford (left) and Romelu Lukaku celebrate Manchester United's second goal in their 2-1 win over Liverpool on Saturday.