ibusinesslines.com
ibusinesslines.com December 13, 2018


BRCA gene does not alter breast cancer survival rates

13 January 2018, 06:00 | Myron Mathis

BRCA gene does not alter breast cancer survival rates

The BRCA test consists of a simple blood sample with risks and benefits to be considered. The Food and Drug Administration on Friday cleared the first treatment for patients with advanced breast cancer caused by BRCA mutations which are genetic defects

BRCA mutations can cause cancer because the DNA self-repair mechanisms can malfunction. "For the portion of the 155,000 women in the U.S. living with metastatic breast cancer who have an inherited BRCA mutation, today's news is encouraging".

A study of nearly 3,000 British women found that preventative surgery - like a double mastectomy - straight after being diagnosed with this type of breast cancer did not improve survival over 10 years. About 12 percent of the patients had a BRCA mutation, yet again confirming the association between this "faulty gene" and breast cancer.

The study involved 127 hospitals across the United Kingdom and included 2,733 women aged 18-40 years who had recently been diagnosed with breast cancer for the first time.

Having a faulty BRCA gene - either BRCA1 or BRCA2 - is known to increase a woman's risk of breast cancer.

Dr. Susan M. Domchek, Executive Director of the Basser Center for BRCA at the Abramson Cancer Center of the University of Pennsylvania and a national leader on the OlympiAD trials, said: "Patients diagnosed with BRCA-related metastatic breast cancer are often younger than other breast cancer patients, and their disease is often much more aggressive and hard to treat".

Martin Ledwick, Cancer Research UK's Head Information Nurse, said: "Although BRCA faults increase the risk of young women developing cancer, their outlook once diagnosed is no worse than that for young women with breast cancer who don't carry the BRCA gene faults".

The approval expands the use of olaparib to include the treatment of patients with BRCA-mutated HER2-negative metastatic breast cancer.


Young women with the BRCA gene mutation that prompted actress Angelina Jolie's pre-emptive and much-publicised double mastectomy are not more likely to die after a breast cancer diagnosis, scientists said Friday.

At the same time, 72 percent of the women who used the decision aid recognized that they could wait a few weeks to make an informed treatment choice without affecting their survival odds, compared with just 54 percent for the other women.

Angelina Jolie made headlines when she underwent preventative surgery after learning she had an up to 87% chance of developing breast cancer.

"However, our findings suggest that this surgery does not have to be immediately undertaken along with the other treatment".

Susan Domchek, MD, executive director of the Basser Center for BRCA at the University of Pennsylvania's Abramson Cancer Center and a national leader on the OlympiAD trials that led to FDA approval of olaparib for the treatment of breast cancer, is available today for phone and satellite uplink interviews related to the news.

This surgery did not appear to improve their chances of survival at the 10-year mark.

She added: "In view of this, younger women with breast cancer can take time to discuss whether radical breast surgery is the right choice for them as part of a longer-term risk reducing strategy".



Other News

Trending Now

UK, LFUCG hosting Martin Luther King Jr. Day celebration
The 2 p.m. presentation is educational, family-friendly and includes song, dance spoken word and poetry vignettes. Monday's service is sponsored by the Topeka Center for Peace and Justice as part of the Living the Dream program.

Elliott DeGeneres, proud father of Ellen DeGeneres
DeGeneres, who is originally from Louisiana, remembered that growing up, her dad only took her on one family vacation. She further explained he was a Christian Scientist his whole life and never had medicine or went to a doctor.

'Mummy, what's felching?' Tot gets smut served by Android app
About 60 apps were recently deleted by Google after the company learned that a bug was placing pornographic ads inside the apps. Reports, however, say this ability to make Duo calls to even those who aren't using the app is now restricted to Android users.

Saudi Airstrikes Hit North Yemen Market, Killing 11 Civilians
Within 48 hours, the capital of Sanaa witnessed the killing of two Houthi militia leaders by the unidentified armed groups.

Mark Hamill says the Force is strong in Ireland
This would certainly be taking the idea to an extreme, but we're certainly led to believe that what Luke does is extreme. We don't know much else about " Episode IX ". "The one between Kylo and Rey and Snoke's people is just jaw dropping".

Angela Merkel's party reaches breakthrough in German coalition talks
Friday's agreement states that the number of new asylum-seekers shouldn't exceed a range of 180,000-220,000 annually. Merkel highlighted promises to hire 15,000 more police officers and 2,000 people to strengthen the justice system.

Cubs' Bryant gets $10.85M, record for 1st arbitration eligible
No Cub has ever gone to arbitration with Theo Epstein in charge and it doesn't look like that will change this year. On Friday morning, the Cubs officially avoided arbitration with two pitchers just ahead of the noon deadline.