The president acknowledged the speculation Tuesday, responding to a question about whether he could beat Winfrey during a bipartisan meeting with senators at the White House.
"I don't think she's going to run", Trump said. "I like Oprah", he added.
Trump has tweeted about Oprah over a dozen times and posted her inspirational messages and quotes.
Beyond her rise from poverty, Winfrey's success as a multidimensional media figure has come from promoting ways for women to assert themselves, typically outside the political arena.
And after some pushing and prodding from her co-anchors, King said she agreed. Her appeal extended well beyond her celebrity, some said, citing her compassion, kindness and devotion to helping others as a badly needed change after Trump.
This isn't the first time Winfrey's presidential run has been shut down.
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