ibusinesslines.com December 12, 2018

Ibuprofen may temporarily reduce male fertility

09 January 2018, 07:37 | Justin Tyler

Researchers came to this somewhat disturbing conclusion after splitting 31 male test subjects between the ages of 18 and 35 into two groups; they gave one group ibuprofen, and the other group a placebo.

It occurs when men have normal levels of testosterone but higher levels of luteinizing hormone (LH) - a chemical that stimulates the production of testosterone.

The study's findings come at a time when male infertility has become a big issue.

Ibuprofen is an anti-inflammatory drug that is mostly prescribed for minor pains, headaches and colds that sometimes develop fever in sick patients.

Those who took the ibuprofen were more likely to have indications of testicular problems - including a condition called compensated hypogonadism that affects reproductive health - meaning men are less likely to be able to father a child.

Epidemiological studies have shown that NSAID exposure was associated with reduced testosterone and congenital malformations; another study showed a drop in a testosterone metabolite among men who were taking ibuprofen regularly.

A study of nearly 1,000 men tracked for seven years found nearly twice as many with testosterone deficiency - or hypogonadism - died as did those with normal levels.

He said investigating ibuprofen-induced compensatory hypogonadism is crucial as the disorder is "generally associated with smoking and ageing".

A study has found links between taking ibuprofen and lower fertility among young men.

According to a new study, prolonged use may decrease the testes' ability to produce testosterone.

"The effects were very mild even after six weeks of regular consumption of ibuprofen, which is longer than is usually recommended in practice, so this data should not concern men who occasionally take ibuprofen for pain relief", added Imperial College London senior clinical lecturer in endocrinology Ali Abbara.

Based on the results, researchers don't recommend taking ibuprofen for longer than the 10 days it says on the packet. No direct effect on fertility was shown, but the results of this initial study suggest that it warrants further investigation. They looked at the impact of ibuprofen on their health over six weeks, by performing tests on cells and tissue samples.

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