ibusinesslines.com
ibusinesslines.com July 21, 2018


Immunotherapy is safe for people with Type 1 Diabetes

12 August 2017, 01:56 | Jodi Jackson

Immunotherapy is safe for people with Type 1 Diabetes

Immunotherapy is safe for people with Type 1 Diabetes

Immunotherapies are regularly used in patients with autoimmune conditions, such as multiple sclerosis, rheumatoid arthritis, and lupus.

United Kingdom scientists may finally have uncovered an immune therapy that works against type 1 diabetes, based on the results of a small trial reported in Science Translational Medicine.

Researchers have been wary of pursuing the strategy in diabetes, anxious that it could accelerate or strengthen the immune system's attack on insulin-producing pancreatic cells, or cause risky allergic reactions.

Just as lab-produced chemical snippets of peanuts accustom an overactive immune system to the eventual introduction of real peanuts, the researchers hoped that the chemical flag they devised would teach the immune systems of newly diagnosed diabetics to recognize insulin and call off their attack on its source. As many as 1.25 million Americans are living with type 1 diabetes, and the autoimmune disorder's prevalence has been increasing in recent decades, with roughly 40,000 people diagnosed each year. The authors of the new study call their experimental treatment "an appealing strategy for prevention", both in the earliest stages of Type 1 diabetes and in children who are at high genetic risk of developing the disease.

Dr. Mark Peakman, a professor of clinical immunology at King's College London in England, said they found that the immunotherapy had the potential to stop the attacks on beta cells that make insulin.


Scientists are a step closer to finding a cure for diabetes, after they successfully created insulin-producing cells from skin using stem cell techniques.

Results showed there was no evidence of toxic side effects or accelerated B-cell destruction during the trial, nor during the six-month follow up period.

A larger study is needed to determine efficacy, but the small study has proven the safety profile of immunotherapy and its promising future as a therapy for treating type I diabetes. The non-treatment group, to the contrary, gradually needed more and more insulin doses in order to keep glycemic levels in check.

"We still have a long way to go, but these early results suggest we are heading in the right direction", he added. "The peptide technology used in our trial is not only appears to be safe for patients at this stage, but it also has a noticeable effect on the immune system", said Peakman.



Other News

Trending Now

Rite Aid Corporation (NYSE:RAD) Experiences Heavier than Usual Trading Volume
Equitec Proprietary Markets Llc decreased Dell Technologies Inc stake by 104,557 shares to 7,043 valued at $387,000 in 2016Q4. On average, equities analysts anticipate that Rite Aid Corporation will post ($0.09) earnings per share for the current year.

Wall St stops stocks' bleeding, for now; gold, yen tick up
The index ended up 4.93 points at 16.04, the highest level since November 8, when Trump was elected president. They were down 0.7 percent at $48.24 per barrel, on track for a weekly loss of 2.7 percent.

MI woman killed by hippo while on African safari
But August 5 would be Kirken's last post - perhaps eerie now - as she wrote about witnessing a massive migration. She was widely known in the community as one of the founding members of the Rochester Area Women's Fund .

Redskins LB Trent Murphy out for season with ACL injury
The Washington Redskins selected Murphy in the second round of the 2014 NFL Draft after a stellar career at Stanford. Murphy, who started 23 games in his first two years, played in all 16 games as a reserve last year.

Two Barred From Iranian National Soccer Team For Playing Against Israeli Club
Shojaei was instrumental in helping Iran secure a spot in the 2018 World Cup, playing for 70 minutes against Uzbekistan. The comments set off vigorous discussion on social media in Iran, where soccer is the most popular sport.

30 kids die at UP hospital in 48 hrs
The problems are compounded by cases of shoddy medical treatment. According to reports, the children died due to lack of oxygen. Rahul Gandhi said the BJP government must punish the guilty.

Houston man finds abandoned newborn in the bushes covered with these
The baby is recovering in pre-natal ICU at Texas Children's Hospital and "is doing wonderful", Gilliland told the Daily News. Inside they found two people, including a 21-year-old woman who admitted to being the baby's mother , according to KPRC .